Synthon

In chemistry, a synthon is an imaginary or hypothetical chemical species used in retrosynthetic analysis, a method of breaking apart complicated organic compounds to plan out how to make them with organic synthesis.[1] The term was coined by chemist E. J. Corey, who won the Nobel Prize in Chemistry for his work on synthesis.

Most synthons are too unstable to exist in a real reaction. A real synthesis instead uses a synthetic equivalent for a synthon. For example, Grignard reagents like methylmagnesium chloride (CH3MgCl) are synthetic equivalents of carbanions like methylide (CH−3).

References

  1. ↑ Corey, E. J. (1967). "General methods for the construction of complex molecules". Pure and Applied Chemistry. 14: 19–38. doi:10.1351/pac196714010019.
This article is issued from Wikipedia. The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.