Restless leg syndrome (also restless legs syndrome) is a serious neurological disorder. It involves an irresistible urge to move certain regions of the human body to stop odd or uncomfortable sensation. This condition often involves the legs, torso, the head or the arms. Moving an affected part of the body modulates sensations, which may provide temporary relief. Around 75% of people who have RLS have problems involving iron. Other possible issues include varicose veins, sleep troubles, conditions involving blood sugar, ADHD or fibromyalgia.
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| Inflammation | | Brain |
- Encephalitis
- Viral encephalitis
- Herpesviral encephalitis
- Limbic encephalitis
- Encephalitis lethargica
- Cavernous sinus thrombosis
- Brain abscess
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| Brain and spinal cord | |
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Brain/ encephalopathy | | Degenerative | Extrapyramidal and movement disorders | |
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| Dementia |
- Tauopathy
- Frontotemporal dementia/Frontotemporal lobar degeneration
- Lewy bodies dementia
- Posterior cortical atrophy
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| Mitochondrial disease | |
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| Demyelinating |
- Autoimmune
- Inflammatory
- Multiple sclerosis
- For more detailed coverage, see Template:Demyelinating diseases of CNS
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Episodic/ paroxysmal | |
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| CSF |
- Intracranial hypertension
- Hydrocephalus
- Normal pressure hydrocephalus
- Choroid plexus papilloma
- Idiopathic intracranial hypertension
- Cerebral edema
- Intracranial hypotension
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| Other |
- Brain herniation
- Reye syndrome
- Hepatic encephalopathy
- Toxic encephalopathy
- Hashimoto's encephalopathy
- Static Encephalopathy
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| Both/either | | Degenerative | | SA |
- Friedreich's ataxia
- Ataxia–telangiectasia
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| MND |
- UMN only:
- Primary lateral sclerosis
- Pseudobulbar palsy
- Hereditary spastic paraplegia
- LMN only:
- Distal hereditary motor neuronopathies
- Spinal muscular atrophies
- SMA
- SMAX1
- SMAX2
- DSMA1
- Congenital DSMA
- Spinal muscular atrophy with lower extremity predominance (SMALED)
- SMALED1
- SMALED2A
- SMALED2B
- SMA-PCH
- SMA-PME
- Progressive muscular atrophy
- Progressive bulbar palsy
- Fazio–Londe
- Infantile progressive bulbar palsy
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